ONCOTHEIS

Evaluation of cytokine modulators in OncoCilAir™ lung cancer tissues

Elevated levels of cytokines in the tumour microenvironment enhance the metastatic potency of malignant cells and correlate with tumour progression.

cytokines

Because it mimics the tumour environment (human pulmonary tumour nodules surrounded by normal epithelium and fibroblasts), the OncoCilAir™ model allows the in vitro monitoring of cytokines release during the progression of the disease, as well as the evaluation of cytokine modulators as anticancer.

Cytokines analysis is done by ELISA from tissue culture supernatant. The unique lifespan of the model (>3month) as well as the non-destructive nature of the assay enable acute, long term or repeated cytokines dosing.

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