OncoCilAir™ is a novel in vitro 3D human lung cancer model which combines a functional reconstituted human airway epithelium, human lung fibroblasts and lung adenocarcinoma cells in a 24 wells transwell insert format.
OncoCilAir™ transwell insert culture (A) with GFP+ adenocarcinoma cells (B) growing as 3D nodules in the human airway epithelium (C).
OncoCilAir™ can be kept in culture for several months, allowing the concurrent testing of drug efficacy, side-toxicity and tumour recurrence.
Typical histological section (H&E) of an OncoCilAir™ culture showing a tumor nodule invading
the surrounding healthy human airway epithelium.
Video microscopy of OncoCilAir™
A cloud of mucus driven by the ciliary beat of the healthy airway component is moving over OncoCilAir ™ adenocarcinoma nodule (GFP+).
Fluorescence recording of adenocarcinoma nodules (GFP+) growing in OncoCilAir tissue culture for 60 days.
Compound efficacy studies
Acute and chronic toxicity
Tumor resistance and relapse
Therapeutic antibodies testing
Nano-cancer therapies testing
Oncolytic virus therapies
Drug delivery (airway/systemic)
Cytokine, metalloproteinase release
To learn more about OncoCilAir™ tissue cultures, please contact us