ONCOTHEIS

OncoCilAir™

A unique human 3D in vitro lung cancer model



OncoCilAir™ is a novel in vitro 3D human lung cancer model which combines a functional reconstituted human airway epithelium, human lung fibroblasts and lung adenocarcinoma cells in a 24 wells transwell insert format.

OncoCilAir ™ transwell
OncoCilAir™ transwell insert culture (A) with GFP+
adenocarcinoma cells (B) growing as 3D nodules
in the human airway epithelium (C).

OncoCilAir™ can be kept in culture for several months, allowing the concurrent testing of drug efficacy, side-toxicity and tumour recurrence.

Human airway epithelium
Typical histological section (H&E) of an OncoCilAir™ culture showing a tumor nodule invading the surrounding healthy human airway epithelium.

Video microscopy of OncoCilAir™


A cloud of mucus driven by the ciliary beat of the healthy airway component is moving over OncoCilAir ™ adenocarcinoma nodule (GFP+).

Fluorescence recording of adenocarcinoma nodules (GFP+) growing in OncoCilAir tissue culture for 60 days.

APPLICATIONS



To learn more about OncoCilAir™ tissue cultures, please contact us